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The effects of iron deficiency anemia on p wave duration and dispersion

Hakki Simsek1, Yilmaz Gunes, Cengiz Demir

  • 1Cardiology Department, Faculty of Medicine, Yuzuncu Yil University, Turkey.

Clinics (Sao Paulo, Brazil)
|January 19, 2011
PubMed

Insights

Iron deficiency anemia is linked to prolonged P wave duration and dispersion, indicating potential cardiac electrical and diastolic function abnormalities. This study highlights a novel association between anemia and cardiovascular changes.

Area of Science:

  • Cardiology
  • Hematology
  • Electrophysiology

Background:

  • Iron status significantly impacts cardiovascular health.
  • Anemia is an independent risk factor for adverse cardiovascular outcomes.
  • P wave dispersion (PWD) is an electrocardiographic marker predicting atrial fibrillation.

Purpose of the Study:

  • To investigate P wave dispersion in patients with iron deficiency anemia (IDA).
  • To explore relationships between PWD and echocardiographic parameters in IDA patients.

Main Methods:

  • Study included 97 patients with IDA and 50 healthy controls.
  • Evaluations involved clinical examination, 12-lead electrocardiography, and transthoracic echocardiography.

Main Results:

  • IDA patients exhibited significantly longer P wave duration (Pmax) and PWD compared to controls.
  • IDA patients showed prolonged mitral inflow deceleration time (DT) and isovolumetric relaxation time (IVRT).
  • Increased heart rate and a higher frequency of diastolic dysfunction were observed in IDA patients.
  • PWD correlated significantly with IVRT, DT, heart rate, anemia presence, and hemoglobin level.

Conclusions:

  • Iron deficiency anemia is associated with prolonged P wave duration and dispersion.
  • IDA may lead to impaired diastolic left ventricular filling.
  • These findings suggest a link between IDA and altered cardiac electrical and diastolic function.
Abstract

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