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Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Reward and neurocomputational processes.

Guido K W Frank1

  • 1Department of Psychiatry, Developmental Brain Research Program, University of Colorado Denver, The Children's Hospital, Gary Pavilion A036/B-130, 13123 East 16th Avenue, Aurora, CO 80045, USA. Guido.Frank@ucdenver.edu

Current Topics in Behavioral Neurosciences
|January 19, 2011
PubMed
Summary
This summary is machine-generated.

Neuroimaging reveals altered dopamine function in the brain

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuroimaging

Background:

  • Neurobiology of eating disorders (EDs) remains largely unknown.
  • Brain imaging studies suggest neurotransmitter alterations in EDs.
  • The brain's reward system is a key behavioral construct in EDs.

Purpose of the Study:

  • Investigate dopamine function in anorexia nervosa (AN) using functional brain imaging.
  • Utilize a translational approach to link computational models with in vivo brain activity.
  • Identify specific biological alterations in psychiatric populations.

Main Methods:

  • Functional brain imaging to assess reward system activation.
  • Translational research integrating basic science models with human brain data.
  • Analysis of dopamine function in individuals with AN.

Main Results:

  • Demonstrated functional brain imaging approach for dopamine assessment in AN.
  • Validated computational models against in vivo reward system activation.
  • Identified specific biological alterations related to AN.

Conclusions:

  • Functional brain imaging can identify dopamine alterations in anorexia nervosa.
  • A translational approach can bridge computational modeling and clinical neuroscience.
  • This method aids in understanding the neurobiology of psychiatric disorders.