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Clinical and radiological features of pediatric cerebellar anaplastic oligodendrogliomas
Sunil V Furtado1, Prasanna K Venkatesh, Nandita Ghosal
1Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, EPIP Area, Whitefield, Bangalore 560066, India. sunilvf@gmail.com
Insights
Anaplastic oligodendrogliomas are rare in children, especially in the cerebellum. Genetic markers like 1p/19q co-deletion significantly influence prognosis in pediatric cases.
Area of Science:
- Neuro-oncology
- Pediatric Neurosurgery
- Molecular Pathology
Background:
- Oligodendrogliomas represent a small percentage of primary brain tumors in both adults and children.
- Anaplastic oligodendrogliomas are a high-grade glioma subtype.
- Pediatric cerebellar oligodendrogliomas are exceptionally rare.
Observation:
- The study presents two unique pediatric cases of anaplastic oligodendroglioma located in the cerebellum.
- Case 1: A well-circumscribed cerebellar lesion with 1p/19q co-deletion.
- Case 2: A diffuse cerebellar lesion with intact 1p/19q.
Findings:
- The patient with a well-circumscribed tumor and 1p/19q co-deletion experienced a favorable outcome.
- The patient with a diffuse tumor and intact 1p/19q had a less favorable outcome.
- Radiological findings correlated with the genetic status and surgical outcomes.
Implications:
- This study highlights the importance of genetic profiling (1p/19q co-deletion) in predicting outcomes for pediatric cerebellar anaplastic oligodendrogliomas.
- Understanding the relationship between radiological features, genetic markers, and clinical course is crucial for treatment planning.
- Further research into rare pediatric brain tumors can improve diagnostic and therapeutic strategies.
Abstract:
Oligodendrogliomas constitute 4-7% of primary intracranial gliomas in adult and 1% of primary central nervous system tumours in children. The authors report two unusual pediatric cases of anaplastic oligodendroglioma occurring in the cerebellum. The patient with a well-circumscribed lesion with 1p/19q co-deletion had a favorable outcome in comparison with the patient with a diffuse lesion and intact 1p/19q. The discussion elucidates the surgical outcome of such pediatric cerebellar anaplastic oligodendrogliomas in relation to their radiological findings.
