Related Experiment Video

Updated: Jun 5, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Abiraterone acetate, a novel adrenal inhibitor in metastatic castration-resistant prostate cancer

Mohamed Salem1, Jorge A Garcia

  • 1Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue/R35, Cleveland, OH 44195, USA.

Current Oncology Reports
|January 19, 2011
PubMed

Insights

Abiraterone acetate improves survival in men with castration-resistant prostate cancer (CRPC). This drug, which inhibits androgen biosynthesis, showed significant benefits in clinical trials for CRPC patients.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • The androgen receptor is central to castration-resistant prostate cancer (CRPC) progression.
  • Current treatments for adrenal androgen production have limitations in efficacy and tolerability.

Purpose of the Study:

  • To review the rationale and clinical development of abiraterone acetate for CRPC.
  • To highlight abiraterone acetate's efficacy and safety in treating metastatic CRPC.

Main Methods:

  • Review of clinical trials investigating abiraterone acetate in CRPC.
  • Analysis of a randomized phase 3 trial in docetaxel-refractory CRPC patients.

Main Results:

  • Abiraterone acetate demonstrated a survival improvement in metastatic CRPC patients (14.8 vs 10.9 months).
  • The compound irreversibly inhibits CYP17, a key enzyme in androgen biosynthesis.

Conclusions:

  • Abiraterone acetate is a safe and effective treatment for men with CRPC.
  • Further trials are evaluating abiraterone acetate in earlier treatment settings for prostate cancer.

More Related Videos

Serum and Plasma Copy Number Detection Using Real-time PCR09:21

Serum and Plasma Copy Number Detection Using Real-time PCR

Published on: December 15, 2017

Murine Prostate Micro-dissection and Surgical Castration08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers01:22

Adrenergic Antagonists: Pharmacological Actions of ɑ-Receptor Blockers

α-Adrenergic antagonists, known as α-blockers, exert their effects by inhibiting α-adrenoceptors, leading to specific physiological actions. α1-blockers and α2-blockers have distinct pharmacological actions and therapeutic applications.
α1-blockers: These drugs inhibit α1-adrenoceptors on smooth muscle cells, resulting in vasodilation. This vasodilation lowers blood pressure, making α1-blockers valuable in treating hypertension. Additionally, α1-blockers effectively address urinary obstruction...
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...