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Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes
J Surrallés1, E Carbonell, M Puig
1Departament de Genética i de Microbiologia, Universitat Autónoma de Barcelona, Spain.
Toxicology Letters
|December 1, 1990
Abstract:
The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 micrograms/ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes.