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Soy allergy following early soy feeding in neonates

Nimrod Nachmias1, Yaakov Landman, Yehuda L Danon

  • 1Kipper Institute of Immunology, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

The Israel Medical Association Journal : IMAJ
|January 20, 2011
PubMed

Insights

Early soy-based formula supplementation in newborns does not appear to increase the risk of soy allergy. This study followed 982 infants for six months, finding no significant allergic reactions to soy formula.

Area of Science:

  • Pediatrics
  • Allergology
  • Neonatology

Background:

  • Concerns exist regarding potential milk allergy increase from humanized milk formula in neonates.
  • Limited prospective studies evaluate the allergenic effects of early soy-based formula (SBF) feeding.

Purpose of the Study:

  • To determine the prevalence of soy allergy in infants introduced to SBF within the first three days of life.

Main Methods:

  • A cohort of 982 healthy, full-term infants receiving routine SBF supplementation was monitored.
  • In-hospital feeding data was collected, and parents were interviewed monthly for six months about feeding and allergy symptoms.

Main Results:

  • 99% of infants received SBF in the hospital, with 33%-42% continuing at home.
  • No immediate allergic reactions to soy or soy-induced enterocolitis were reported during the follow-up period.

Conclusions:

  • Introducing soy-based formula during the early neonatal period does not seem to elevate the incidence of soy allergy.
  • Infants followed for six months showed no increased prevalence of soy allergy when supplemented with SBF early on.
Abstract

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