Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ingested (oral) adrenocorticotropic hormone (ACTH) inhibits interleukin-17 in the central nervous system after adoptive transfer of T helper (Th)1/Th17 T cells in the mouse model of multiple sclerosis, experimental autoimmune encephalomyelitis.

Journal of the neurological sciences·2023
Same author

The genealogy, methodology, similarities and differences of immune reconstitution therapies for multiple sclerosis and neuromyelitis optica.

Autoimmunity reviews·2022
Same author

Ingested (Oral) Adrenocorticotropic Hormone Inhibits IL-17 in the Central Nervous System in the Mouse Model of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.

ImmunoHorizons·2022
Same author

Anti-Inflammatory Agents: An Approach to Prevent Cognitive Decline in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD·2021
Same author

A proposal: How to study pro-myelinating proteins in MS.

Autoimmunity reviews·2021
Same author

Immune reconstitution therapy in NMOSD.

Multiple sclerosis and related disorders·2021
Same journal

Platycodin D attenuates proliferation, migration, and angiogenesis in RA-stimulated endothelial cells via CD146 modulation.

Autoimmunity·2026
Same journal

CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6.

Autoimmunity·2026
Same journal

Multi-cohort transcriptomic analysis with machine learning identifies interferon-related candidate genes in systemic lupus erythematosus.

Autoimmunity·2026
Same journal

IgA Vasculitis with necrotizing arteritis: a multicenter retrospective study from the French Vasculitis Study Group and systematic review of the literature.

Autoimmunity·2026
Same journal

Global research trends in ferroptosis in autoimmune diseases: a bibliometric and visual analysis (2018-2025).

Autoimmunity·2026
Same journal

Monocyte exhaustion associated with systemic lupus erythematosus.

Autoimmunity·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
06:36

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

Published on: September 8, 2021

Ingested (oral) SST inhibits EAE.

Staley A Brod1, Zachary M Hood

  • 1Department of Neurology, University of Texas Health Science Center, Houston, USA. staley.a.brod@uth.tmc.edu

Autoimmunity
|January 20, 2011
PubMed
Summary
This summary is machine-generated.

Orally administered somatostatin (SST) effectively treats experimental autoimmune encephalomyelitis (EAE) by reducing central nervous system (CNS) inflammation and boosting regulatory T (Treg) cells, offering a novel therapeutic approach for autoimmune diseases.

Related Experiment Videos

Last Updated: Jun 5, 2026

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
06:36

Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

Published on: September 8, 2021

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Protein Therapeutics

Background:

  • Immunoactive proteins like interferon and melanocyte-stimulating hormone show anti-inflammatory effects in experimental autoimmune encephalomyelitis (EAE).
  • Investigating novel protein therapeutics for autoimmune conditions is crucial.

Purpose of the Study:

  • To determine if orally administered somatostatin (SST) exhibits anti-inflammatory properties in EAE.
  • To explore SST's potential as a therapeutic agent for autoimmune neuroinflammation.

Main Methods:

  • Mice with EAE were orally administered somatostatin (SST) or a control.
  • Splenocytes from SST-treated mice were adoptively transferred to assess therapeutic effects.
  • Cytokine profiles (Th1, Th2, Th17) and regulatory T (Treg) cell populations were analyzed in the spleen and central nervous system (CNS).

Main Results:

  • Oral SST administration reduced clinical EAE symptoms and CNS inflammation.
  • SST treatment increased Th2-like cytokines and regulatory T (Treg) cells.
  • Adoptive transfer of SST-induced splenocytes conferred protection against EAE.

Conclusions:

  • Ingested somatostatin (SST) effectively inhibits EAE.
  • SST reduces CNS inflammation by modulating T-cell responses, decreasing Th17 and Th1 cytokines while increasing Th2 cytokines.
  • SST promotes T(reg) cell induction, highlighting its therapeutic potential for autoimmune neuroinflammation.