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Mouse Models Of Helicobacter Infection And Gastric Pathologies
07:43

Mouse Models Of Helicobacter Infection And Gastric Pathologies

Published on: October 18, 2018

Celiac disease, primary biliary cirrhosis and helicobacter pylori infection: one link for three diseases

L Abenavoli, V Arena, F Giancotti

    International Journal of Immunopathology and Pharmacology
    |January 20, 2011
    PubMed

    Insights

    Celiac disease (CD) and primary biliary cirrhosis (PBC) may be linked through increased intestinal permeability and H. pylori infection. Treatment for these conditions improved a patient's health, suggesting a shared pathway.

    Area of Science:

    • Gastroenterology
    • Immunology
    • Hepatology

    Background:

    • The association between celiac disease (CD) and primary biliary cirrhosis (PBC) is increasingly recognized.
    • Primary biliary cirrhosis is considered an autoimmune liver disease with an unknown etiology.
    • Helicobacter pylori infection has been implicated in autoimmune conditions through molecular mimicry.

    Observation:

    • A 36-year-old woman presented with concurrent diagnoses of celiac disease, primary biliary cirrhosis, and Helicobacter pylori infection.
    • The patient underwent a gluten-free diet, ursodeoxycholic acid (UDCA) treatment, and H. pylori eradication therapy.
    • Clinical status showed marked improvement following the combined treatment regimen.

    Findings:

    • This case report suggests that increased intestinal permeability, potentially exacerbated by celiac disease and H. pylori infection, may play a role in the pathogenesis of primary biliary cirrhosis.
    • Successful treatment outcomes support the hypothesis of a link between these conditions.

    Implications:

    • Further research is warranted to elucidate the precise mechanisms linking intestinal permeability, infections, and the development of primary biliary cirrhosis.
    • Understanding these pathogenetic pathways could lead to novel therapeutic strategies for autoimmune liver diseases.

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