Related Experiment Video

Updated: Jun 5, 2026

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
09:19

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization

Published on: March 16, 2020

The morphology and composition of cholesterol-rich micellar nanostructures determine transmembrane protein (GPCR)

Michelle A O'Malley, Matthew E Helgeson, Norman J Wagner

    Biophysical Journal
    |January 20, 2011
    PubMed

    More Related Videos

    Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy10:49

    Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

    Published on: March 5, 2017

    Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)09:45

    Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)

    Published on: February 5, 2022

    Related Concept Videos

    Membrane Domains01:18

    Membrane Domains

    The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
    Protein Domains
    The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
    Micelles01:30

    Micelles

    Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
    Mechanisms of Membrane Domain Formation00:59

    Mechanisms of Membrane Domain Formation

    Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
    Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
    Membrane Fluidity01:23

    Membrane Fluidity

    Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
    Membrane Fluidity01:26

    Membrane Fluidity

    Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
    Mosaic nature of the membrane
    The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
    Fluid Mosaic Model01:19

    Fluid Mosaic Model

    Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...