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Updated: Jun 5, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Thrombin receptor function and cardiovascular disease
1Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0524, USA.
Abstract:
Thrombin, a multifunctional protease generated at sites of vascular injury, is a powerful agonist fora variety of cellular processes important in cardiovascular disease. A recently cloned thrombin receptor has provided a framework for understanding how thrombin, a protease rather than a classic ligand, activates cells. It has also yielded new tools for defining the role of thrombin and its receptor in cellular events. This review discusses a working model for how thrombin activates platelets and other cells, and possible roles for the thrombin receptor in thrombotic, proliferative, and inflammatory processes.
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