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Related Experiment Video

Updated: Jun 5, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Lipoprotein(a) and atherogenesis.

A C Liu¹, R M Lawn

¹Cardiovascular Research Center, Stanford University School of Medicine, Stanford CA 94305-5246, USA.

Trends in Cardiovascular Medicine

|January 20, 2011

Summary

Lipoprotein(a) is a key inherited risk factor for atherosclerosis. Its component, apolipoprotein(a), may promote lipid buildup and affect blood clot breakdown, requiring further human and animal studies.

Area of Science:

Cardiovascular Science
Molecular Biology
Biochemistry

Background:

Lipoprotein(a) is a significant inherited risk factor for atherosclerosis.
Apolipoprotein(a), a component of Lipoprotein(a), plays a crucial role in its atherogenic activities.

Purpose of the Study:

To explore the mechanisms by which apolipoprotein(a) contributes to atherosclerosis.
To investigate the potential roles of apolipoprotein(a) in lipid deposition, fibrinolysis, and smooth muscle cell function.

Main Methods:

In vitro studies were conducted to assess the effects of apolipoprotein(a).
Analysis focused on apolipoprotein(a)'s interactions with the vessel wall and its influence on cellular processes.

Main Results:

Related Experiment Videos

Last Updated: Jun 5, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

In vitro data suggest apolipoprotein(a) may enhance lipid deposition by binding to vessel wall sites.
Apolipoprotein(a) may interfere with fibrinolysis and modulate smooth muscle cell activity.

Conclusions:

In vitro findings indicate potential atherogenic mechanisms involving apolipoprotein(a).
Further in vivo human and animal studies are essential to confirm the physiological significance of these observed mechanisms.