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Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: Jun 5, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Vascular endothelial growth factor.

N Ferrara1

  • 1Department of Cardiovascular Research, Genentech, Inc., South San Francisco, CA 94080, USA.

Trends in Cardiovascular Medicine
|January 20, 2011
PubMed
Summary
This summary is machine-generated.

Vascular Endothelial Growth Factor (VEGF) uniquely promotes blood vessel growth and is crucial for both development and disease. Targeting VEGF offers potential treatments for cancer and conditions with poor blood flow.

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Related Experiment Videos

Last Updated: Jun 5, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

Decellularization and Recellularization Methodology for Human Saphenous Veins
11:35

Decellularization and Recellularization Methodology for Human Saphenous Veins

Published on: July 27, 2018

In Vitro Model of Coronary Angiogenesis
08:03

In Vitro Model of Coronary Angiogenesis

Published on: March 10, 2020

Area of Science:

  • Cardiovascular Biology and Medicine
  • Cellular Biology
  • Molecular Biology

Background:

  • Endothelial cell growth and differentiation are critical for cardiovascular health.
  • Several growth factors regulate angiogenesis, but Vascular Endothelial Growth Factor (VEGF) has unique direct mitogenic effects on endothelial cells.
  • VEGF exists in four isoforms with similar activities but different secretion patterns, acting via paracrine signaling.

Purpose of the Study:

  • To elucidate the role of VEGF in angiogenesis and its therapeutic potential.
  • To investigate VEGF's function in developmental and ovarian angiogenesis.
  • To explore the therapeutic applications of VEGF antagonists and agonists.

Main Methods:

  • Review of existing literature on VEGF and angiogenesis.
  • Analysis of VEGF's molecular properties, including isoforms and signaling pathways.
  • Evaluation of studies investigating VEGF's role in tumor angiogenesis and therapeutic interventions.

Main Results:

  • VEGF is a secreted polypeptide with specific mitogenic effects on endothelial cells.
  • VEGF regulates developmental and ovarian angiogenesis through paracrine action.
  • High VEGF mRNA levels in tumors suggest its role as a tumor angiogenesis factor.
  • Monoclonal antibodies against VEGF inhibit tumor growth in vivo.

Conclusions:

  • VEGF is a key regulator of angiogenesis with significant implications for cardiovascular medicine.
  • VEGF antagonists show promise for treating malignancies and other angiogenic diseases.
  • VEGF protein may be therapeutically useful for inducing neovascularization in ischemic conditions.