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Related Experiment Video

Updated: Jun 5, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

The mouse model for atherosclerosis.

A J Lusis1

  • 1Department of Medicine, Department of Microbiology and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90024-1679, USA.

Trends in Cardiovascular Medicine
|January 20, 2011
PubMed
Summary
This summary is machine-generated.

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Mouse models offer valuable tools for studying atherosclerosis, a complex disease influenced by genetics and environment. Advanced genetic tools and gene manipulation techniques in mice enable detailed research into disease mechanisms.

Area of Science:

  • Cardiovascular Research
  • Genetics and Genomics
  • Animal Models

Background:

  • Atherosclerosis is a complex disease influenced by environmental and genetic factors.
  • Understanding these interactions is crucial for developing effective treatments.
  • Mouse models offer a powerful platform for such investigations.

Purpose of the Study:

  • To highlight the utility of mouse models in studying atherosclerosis.
  • To emphasize the role of genetic and environmental factors in disease development.
  • To showcase advancements in genetic tools for atherosclerosis research.

Main Methods:

  • Utilizing diverse inbred mouse strains with variations in lipoprotein metabolism, diabetes, obesity, and immune regulation.
  • Employing genetic markers to identify genes contributing to complex traits.

Related Experiment Videos

Last Updated: Jun 5, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

  • Applying advanced in vivo gene manipulation techniques.

    • Main Results:

    • Mouse models provide a versatile system for dissecting genetic and environmental influences on atherosclerosis.
    • Genetic markers facilitate the identification of susceptibility genes.
    • Gene manipulation techniques have yielded significant insights into lipoprotein metabolism and atherosclerosis.

    Conclusions:

    • Mouse models are indispensable for complex trait analysis in atherosclerosis research.
    • Genetic and environmental interactions can be effectively studied using these models.
    • Advanced genetic tools in mice accelerate the understanding of disease pathogenesis.