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Effects of immunomodulating therapy in systemic sclerosis

F H van den Hoogen1, A M Boerbooms, L B van de Putte

  • 1Department of Rheumatology, University Hospital Nijmegen, The Netherlands.

Clinical Rheumatology
|September 1, 1990
PubMed

We reviewed studies concerning immunomodulating therapy in systemic sclerosis. These comprise mostly uncontrolled trials and case reports. Some of these studies hint at a possible beneficial effect of antimetabolites (azathioprine, 5-fluoro-uracil and methotrexate), cyclosporine and interferon-gamma. However, to give a clearcut answer on the efficacy of these drugs in systemic sclerosis, controlled studies are urgently needed.

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