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Intravenous Injections in Neonatal Mice
Published on: November 11, 2014
Intravenous colistin administration in neonates
Mamta Jajoo1, Vishal Kumar, Manish Jain
1Department of Pediatrics, Maulana Azad Medical College & Associated Chacha Nehru Bal Chikitsalaya, New Delhi, India.
The Pediatric Infectious Disease Journal
|January 20, 2011
Summary
Intravenous colistin (colistimethate) is safe and effective for treating multidrug-resistant Gram-negative infections in critically ill neonates. This study shows favorable outcomes in sepsis, pneumonia, and meningitis cases.
Area of Science:
- Neonatal Intensive Care
- Infectious Diseases
- Pharmacology
Background:
- Nosocomial infections caused by multidrug-resistant Gram-negative pathogens pose a significant challenge in intensive care units.
- Parenteral colistin use has resurged, but safety and efficacy data in neonates are limited.
- This study addresses the need for data on intravenous colistin (colistimethate) in critically ill neonates.
Purpose of the Study:
- To evaluate the efficacy and safety of intravenous colistimethate in treating sepsis in critically ill term and preterm neonates.
- To assess the clinical outcomes and microbiological clearance in neonates receiving colistimethate.
- To identify potential adverse events associated with colistimethate use in this population.
Main Methods:
- Retrospective review of neonates treated with colistimethate in a tertiary care neonatal intensive care unit from January 2009 to December 2009.
- Analysis of treatment courses, dosages, pathogen profiles, and clinical outcomes.
- Evaluation of microbiological clearance and adverse events, including renal function.
Main Results:
- Eighteen neonates received 21 courses of colistimethate for various infections, including pneumonia, bloodstream infections, and meningitis.
- Common pathogens included Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa.
- A favorable clinical outcome was observed in 76% of courses, with microbiological clearance in 17 courses. Two neonates experienced increased serum creatinine.
Conclusions:
- Intravenous colistimethate demonstrates safety and efficacy in treating multidrug-resistant Gram-negative infections in neonates.
- The findings support the use of colistimethate in preterm and extremely low birth weight neonates.
- Further research may be warranted to optimize dosing and monitor for potential adverse effects.
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