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Updated: Jun 5, 2026
Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
Mammographic density and its interaction with other breast cancer risk factors in an Asian population
1Centre For Molecular Epidemiology, National University of Singapore, Blk MD3, 16 Medical Drive, Singapore 117597, Singapore.
Background:
Joint effects of mammographic density and other risk factors on breast cancer risk remain unclear.
Methods:
From The Singapore Breast Screening Project, we selected 491 cases and 982 controls. Mammographic density was measured quantitatively. Data analysis was by conditional logistic regression.
Results:
Density was a significant risk factor, adjusting for other factors. Density of 76-100% had an odds ratio of 5.54 (95% CI 2.38-12.90) compared with 0-10%. Density had significant interactions with body mass index and oral contraceptive use (P=0.02).
Conclusions:
Percent density increases breast cancer risk in addition to effects of other risk factors, and modifies the effects of BMI and OCs.
