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Risk factors for hilar cholangiocarcinoma: a case-control study in China
Wen-Ke Cai1, Hui Sima, Ben-Dong Chen
1Department of Biliary Surgery II, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China. caiwenke002@126.com
Insights
Biliary tract stones and parasitic liver diseases are significant risk factors for hilar cholangiocarcinoma (HC) in the Chinese population. These conditions increase the likelihood of developing HC, highlighting the importance of managing them.
Area of Science:
- Hepatobiliary Surgery
- Gastroenterology
- Epidemiology
Background:
- Hilar cholangiocarcinoma (HC) is a challenging malignancy with complex risk factors.
- Understanding pre-existing medical conditions associated with HC is crucial for early detection and prevention.
Purpose of the Study:
- To investigate the association between hilar cholangiocarcinoma (HC) and various pre-existing medical conditions.
- To identify specific risk factors contributing to the development of HC in the Chinese population.
Main Methods:
- A case-control study involving 313 HC patients and 608 healthy controls.
- Logistic regression analysis was employed to calculate adjusted odds ratios (OR) for identified conditions.
Main Results:
- Significantly higher prevalence of biliary tract stones (choledocholithiasis, hepatolithiasis, cholecystolithiasis) and prior cholecystectomy in HC patients.
- Increased odds of HC associated with parasitic liver diseases, including biliary ascariasis, liver fluke, and liver schistosomiasis.
Conclusions:
- Biliary tract stone disease is a significant risk factor for HC.
- Parasitic liver diseases are strongly associated with an increased risk of developing HC.
- Findings emphasize the role of these conditions in HC pathogenesis within the Chinese population.
Aim:
To study the association between hilar cholangiocarcinoma (HC) and pre-existing medical conditions.
Methods:
Three hundred and thirteen HC patients admitted to the Eastern Hepatobiliary Surgery Hospital (Shanghai, China) in 2000-2005 and 608 healthy controls were enrolled in this study. Association between HC and pre-existing medical conditions was studied with their adjusted odds ratio (OR) calculated by logistic regression analysis.
Results:
The prevalence of choledocholithiasis (adjusted OR = 2.704, P = 0.039), hepatolithiasis (adjusted OR = 3.278, P = 0.018), cholecystolithiasis (adjusted OR = 4.499, P < 0.0001), cholecystectomy (adjusted OR = 7.012, P = 0.004), biliary ascariasis (adjusted OR = 7.188, P = 0.001), liver fluke (adjusted OR = 10.088, P = 0.042) and liver schistosomiasis (adjusted OR = 9.913, P = 0.001) was higher in HC patients than in healthy controls.
Conclusion:
Biliary tract stone disease (choledocholithiasis, hepatolithiasis, cholecystolithiasis) and parasitic liver disease (biliary ascariasis, liver fluke, liver schistosomiasis) are the risk factors for HC in Chinese population.
