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Updated: Jun 5, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
Pharmacokinetics and antitumor effects of the drug containing TNF-α in nanoparticles
S G Gamaley1, A V Bateneva, G M Sysoeva
1Institute of Medical Biotechnology, Vector Center of Virology and Biotechnology, Novosibirsk Region, Berdsk, Russia. gamalei58@mail.ru
Abstract:
Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue.
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