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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Related Experiment Video

Updated: Jun 5, 2026

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

Optical probes and the applications in multimodality imaging.

Yang Liu¹, Gang Yu, Mei Tian

¹Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Contrast Media & Molecular Imaging

|January 20, 2011

Summary

This summary is machine-generated.

Multimodal imaging probes combine optical imaging with other modalities for enhanced biomedical research. This review covers available probes for in vivo imaging, leveraging optical methods for richer data.

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Area of Science:

Biomedical research
Molecular imaging
Optical imaging

Background:

Optical imaging, including fluorescence and bioluminescence imaging, is a key visualization method in biomedical research.
Multimodal probes, detectable by two or more imaging modalities, offer comprehensive insights.
Optical methods are crucial in multimodality imaging due to probe availability and cost-effectiveness.

Purpose of the Study:

To review available multimodal imaging probes for in vivo applications.
To highlight probes combining optical imaging with other modalities.

Main Methods:

Literature review of multimodal imaging probes.
Focus on probes integrating optical imaging (fluorescence, bioluminescence) with other modalities.

Main Results:

Description of various multimodal imaging probes for in vivo use.
Emphasis on the synergistic benefits of combining optical imaging with other techniques.

Conclusions:

Multimodal probes enhance in vivo imaging by integrating optical techniques with other modalities.
The development of these probes advances molecular imaging and biomedical research capabilities.