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Synthesis and radioprotective properties of pulvinic acid derivatives
Antoine Le Roux1, Stéphane Meunier, Thierry Le Gall
1Laboratory of Functional Chemo-Systems, UMR 7199, Université de Strasbourg, and Centre régional de Lutte contre le Cancer Paul Strauss 3, rue de la Porte de l’Hôpital, 74, route du Rhin 67401 Illkirch-Graffenstaden, France.
Abstract:
A high-throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton-like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of their radioprotective efficacy in cell culture. Using a cell-based fluorescent assay, we show that some of these compounds have a pronounced ability to prevent cell death caused by radiation and to allow the subsequent resumption of proliferation. Thus, PADs may be considered as a novel class of radioprotective agents.
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