Related Experiment Video
Updated: Jun 5, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
Leptin and adiponectin in obese and non-obese subjects with asthma
Andréa Lessard1, Julie St-Laurent, Hélène Turcotte
1Centre de Recherche Clinique, l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, QC, Canada.
Objective:
To understand the role of leptin and adiponectin in obese asthmatics.
Methods:
We compared serum leptin, adiponectin and sputum leptin levels in 44 non-obese and 44 obese subjects.
Results:
We found higher serum leptin (P < 0.0001) and lower adiponectin (P = 0.0002) levels in obese asthmatics. Sputum leptin was correlated with body mass index (BMI; r = 0.34, P = 0.03) and serum leptin (r = 0.43, P = 0.005); however, this last correlation was not significant after adjusting for BMI (r = 0.26, P = 0.11).
Conclusion:
Airway inflammation in obese asthmatics may present a different pattern involving leptin. Sputum leptin levels may partially originate from systemic circulation, with other contributing mechanisms.
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