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Related Experiment Video

Updated: Jun 5, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

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Published on: January 29, 2013

Comparison of peripheral endothelial function in shift versus nonshift workers.

Alois Suessenbacher1, Miriam Potocnik, Jakob Dörler

  • 1Department of Internal Medicine III, Innsbruck Medical University, Innsbruck, Austria. alois.suessenbacher@i-med.ac.at

The American Journal of Cardiology
|January 21, 2011
PubMed
Summary
This summary is machine-generated.

Shift working is linked to higher cardiovascular risk due to peripheral endothelial dysfunction. This study found shift workers had poorer endothelial function, suggesting a mechanism for increased heart disease risk.

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Area of Science:

  • Cardiovascular Health
  • Occupational Medicine
  • Vascular Biology

Background:

  • Shift working is associated with increased cardiovascular morbidity.
  • Peripheral endothelial dysfunction is an early marker of atherosclerosis and cardiovascular risk.
  • The link between shift working and endothelial dysfunction remains uninvestigated.

Purpose of the Study:

  • To investigate whether shift working is associated with peripheral endothelial dysfunction.
  • To compare endothelial function between male shift workers (SWs) and nonshift workers (NSWs).

Main Methods:

  • Recruited 48 male SWs and 47 age- and risk-factor-matched NSWs from a glass manufactory.
  • Assessed peripheral endothelial function using the EndoPAT technique to measure the peripheral arterial tone (PAT) index.
  • Matched SWs and NSWs on key cardiovascular risk factors and workplace.

Main Results:

  • Shift workers exhibited a significantly reduced PAT index (1.73 ± 0.4) compared to nonshift workers (1.94 ± 0.5), indicating endothelial dysfunction.
  • Despite higher rates of physical activity in SWs, their endothelial function was impaired.
  • Regular physical activity improved PAT index in NSWs but not in SWs, highlighting a potential detrimental effect of shift work.

Conclusions:

  • Shift working is associated with peripheral endothelial dysfunction.
  • Endothelial dysfunction may be a contributing factor to the elevated cardiovascular risk observed in shift workers.
  • Further research is warranted to explore interventions mitigating cardiovascular risk in shift workers.