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Disappearance of angina pectoris by lipid-lowering in type III hyperlipoproteinemia

Eun Jeung Cho1, Yun Joo Min, Min Seok Oh

  • 1Department of Internal Medicine, College ofMedicine, Chung-Ang University, Seoul, Korea.

The American Journal of Cardiology
|January 21, 2011
PubMed

Insights

Type III hyperlipoproteinemia, a rare genetic disorder, can be effectively managed. Combination therapy with atorvastatin and fenofibrate led to the regression of coronary lesions and improved symptoms in a patient with this condition.

Area of Science:

  • Cardiology
  • Genetics
  • Metabolic Disorders

Background:

  • Type III hyperlipoproteinemia is a rare genetic disorder causing high cholesterol and triglycerides.
  • It is linked to an increased risk of premature atherosclerotic vascular disease.
  • Apolipoprotein E2/E2 homozygotes are particularly susceptible due to remnant lipoprotein accumulation.

Observation:

  • A 55-year-old woman with type III hyperlipoproteinemia presented with skin lesions and stable angina pectoris.
  • Diagnosis was confirmed via lipid levels, electrophoresis, and apolipoprotein E genotyping.

Findings:

  • One year of combination therapy with atorvastatin and fenofibrate resolved skin xanthomata.
  • The patient experienced symptom resolution, negative exercise electrocardiographic results, and confirmed coronary lesion regression via CT angiography.

Implications:

  • This case highlights the potential for medical therapy to induce regression of uncomplicated coronary lesions in type III hyperlipoproteinemia.
  • Effective management can significantly improve clinical outcomes and reduce cardiovascular risk in affected individuals.

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