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Gastritis in Alaskan racing sled dogs
J W Ritchey1, M S Davis, M A Breshears
1Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. jerry.ritchey@okstate.edu
Journal of Comparative Pathology
|January 21, 2011
Summary
Alaskan racing sled dogs develop gastric ulcers under racing stress. This study reveals unique immune-mediated inflammation in their gastric mucosa, similar to human lymphocytic gastritis.
Area of Science:
- Veterinary Medicine
- Gastroenterology
- Canine Sports Medicine
Background:
- Alaskan racing sled dogs are a recognized model for exercise-induced gastric disease.
- Long-distance racing imposes significant physiological stress on these animals.
Purpose of the Study:
- To investigate the temporal development of microscopic gastric lesions in sled dogs during endurance racing.
- To characterize the nature of gastric inflammation and epithelial changes associated with racing stress.
Main Methods:
- Endoscopic examination and tissue sampling of gastric mucosa from exercising (Group I) and non-exercising (Group II) conditioned dogs.
- Histopathology, microscopical scoring, immunohistochemistry (IHC), and apoptotic cell detection were performed.
- Analysis focused on epithelial lesions, inflammatory infiltrates, and cellular markers (CD3, CD79).
Main Results:
- Exercising dogs (Group I) showed more severe epithelial lesions, including ulcers, compared to non-exercising dogs (Group II).
- Group II dogs exhibited more intense mucosal inflammatory infiltrates, primarily composed of CD3(+) T cells.
- A unique interface-type inflammation, obscuring the basement membrane, was observed in both groups and resembles human lymphocytic gastritis.
Conclusions:
- Racing stress in sled dogs leads to gastric ulcers and a distinct pattern of lymphocytic inflammation.
- The interface-type inflammation suggests a potential immune-mediated mechanism for gastric pathology in these athletes.
- Findings contribute to understanding exercise-induced gastric disease in canine athletes and its parallels with human conditions.
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