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Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

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Hyperintensity on diffusion weighted image along ipsilateral cortical spinal tract after cerebral ischemic stroke: a

Xiang Liu¹, Wei Tian, Lilin Li

¹Department of Neuroradiology, Beijing Tiantan Hospital, #6 Tiantan Xili, Beijing, China. Xiang Liu@URMC.Rochester.edu

European Journal of Radiology

|January 21, 2011

Summary

Hyperintensity on diffusion-weighted imaging (DWI) after stroke indicates Wallerian degeneration, characterized by decreased diffusion tensor imaging (DTI) values. Fractional anisotropy (FA) predicts motor function recovery following ischemic stroke.

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Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

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Area of Science:

Neuroimaging
Neurology
Radiology

Background:

Hyperintensity on diffusion-weighted imaging (DWI) along the cortical spinal tract (CST) after brain infarction may indicate motor disability.
The pathophysiology of this DWI finding remains unclear and can be misdiagnosed as a new infarction.

Purpose of the Study:

To analyze diffusion tensor imaging (DTI) changes in patients exhibiting ipsilateral CST hyperintensity post-stroke.
To investigate the relationship between DTI metrics and motor function outcomes.

Main Methods:

Eight patients with ipsilateral CST hyperintensity on DWI post-stroke were included (positive group).
Twelve patients without this hyperintensity served as the reference group.
Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in the cerebral peduncle were measured and correlated with motor function scales.

Main Results:

Serial DTI showed that DWI hyperintensity is transient.
Significantly decreased ipsilateral ADC and FA values were observed compared to the contralateral side (p<0.05).
Ipsilateral FA significantly correlated with motor function scores in both groups (r=0.875, 0.738; p=0.004, 0.006).

Conclusions:

DWI hyperintensity represents a transient phase of Wallerian degeneration after ischemic stroke.
This process is characterized by decreased ipsilateral ADC and FA.
Ipsilateral FA is a potential predictor of neurological motor function outcome.