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Updated: Jun 5, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Pyridylmethylthio derivatives as VEGF inhibitors: part 2
Hisashi Tajima1, Takahiro Honda, Kenji Kawashima
1Research and Development Center, Santen Pharmaceutical Co. Ltd, 8916-16 Takayama-cho Ikoma-shi, Nara 630-0101, Japan. hisashi.tajima@santen.co.jp
Bioorganic & Medicinal Chemistry Letters
|January 21, 2011
Abstract:
Optimization of compounds 5 and 6 led to the discovery of VEGF inhibitor 10g which reduced CYP inhibition. It was highly active in vitro (VEGF induced HUVEC proliferation assay) and showed efficacies in three disease models in vivo (cancer, RA, and AMD).
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