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Related Concept Videos

Drug Product Stability01:16

Drug Product Stability

The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
Indirect-Acting Cholinergic Agonists: Pharmacokinetics01:22

Indirect-Acting Cholinergic Agonists: Pharmacokinetics

Indirect-acting cholinergic agonists, or anticholinesterases, enhance the body's cholinergic activity by inhibiting acetylcholine's breakdown. They are categorized as reversible or irreversible agents based on their mechanism of action. They are further classified into short-acting, intermediate-acting, and long-acting agents based on their duration of action.
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they are...
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics01:11

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics

All neuromuscular blocking agents are injected intravenously because they are poorly absorbed from the GI tract. Rapid onset is achieved with intravenous administration, although absorption is also adequate from an intramuscular injection. Since these agents are highly ionized, they do not readily penetrate cell membranes or cross the blood-brain barrier.
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...

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Related Experiment Video

Updated: Jun 5, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

Is levomepromazine stable over time?

J Hardy1, A O'Shea, C Gilbert

  • 1Department of Palliative and Supportive Care, Mater Health Services, Australia. janet.hardy@mater.org.au

Palliative Medicine
|January 21, 2011
PubMed
Summary
This summary is machine-generated.

Low-dose levomepromazine (methotrimeprazine) effectively controls nausea and vomiting. The drug remains stable in 0.9% sodium chloride solutions within polypropylene syringes for at least 14 days.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy

Background:

  • Levomepromazine (methotrimeprazine) is an antipsychotic medication.
  • It is utilized at low doses for managing nausea and vomiting.

Purpose of the Study:

  • To evaluate the stability of levomepromazine hydrochloride solutions.
  • To determine the stability of Nozinan® diluted in 0.9% sodium chloride and stored in polypropylene syringes.

Main Methods:

  • Levomepromazine hydrochloride (Nozinan®) was diluted in 0.9% sodium chloride.
  • Solutions were prepared at concentrations from 0.13 to 6.25 mg/ml.
  • The diluted drug was stored in polypropylene syringes.

Main Results:

  • Levomepromazine hydrochloride demonstrated stability in the tested solutions.
  • Stability was maintained for a minimum of 14 days under storage conditions.

Conclusions:

  • Levomepromazine hydrochloride is stable in 0.9% sodium chloride at concentrations of 0.13–6.25 mg/ml.
  • Polypropylene syringes are suitable for storing these diluted solutions for up to 14 days.