Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Treatment of Persisting Symptoms after Concussion with Repetitive Transcranial Magnetic Stimulation: A Double-Blinded, Randomized, Controlled Trial.

Journal of neurotrauma·2026
Same author

A national curriculum and community of practice for health services and policy research training: Insights from the Health System Impact Fellowship National Cohort Training Program (HSIF NCTP).

Learning health systems·2025
Same author

Randomized Controlled Trial of Transcranial Direct Current Stimulation over the Supplementary Motor Area in Tourette Syndrome.

Movement disorders clinical practice·2024
Same author

Dopamine transmission in the tail striatum: Regional variation and contribution of dopamine clearance mechanisms.

Journal of neurochemistry·2024
Same author

Robotic mapping of motor cortex in children with perinatal stroke and hemiparesis.

Human brain mapping·2022
Same author

Anti-inflammatory role of GM1 and other gangliosides on microglia.

Journal of neuroinflammation·2022
Same journal

Cortex-anchored sensor-space harmonics for event-related EEG.

Journal of neural engineering·2026
Same journal

Neural mechanisms of mixed speech and grasp representation in sensorimotor cortices.

Journal of neural engineering·2026
Same journal

Developing a binary communication protocol between biological neural networks using virtual white matter.

Journal of neural engineering·2026
Same journal

Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation.

Journal of neural engineering·2026
Same journal

A neural mass modelling framework for evaluating EEG source localisation of seizure activity.

Journal of neural engineering·2026
Same journal

Functional and effective connectivity methods from SEEG for characterizing epileptogenic networks in refractory epilepsy: a comprehensive review and future directions.

Journal of neural engineering·2026
See all related articles

Related Experiment Video

Updated: Jun 5, 2026

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

Nerve lesioning with direct current.

E Natalie Ravid1, Liu Shi Gan, Kathryn Todd

  • 1Center for Neuroscience, University of Alberta, Edmonton, Alberta, Canada. ravid@ualberta.ca

Journal of Neural Engineering
|January 21, 2011
PubMed
Summary
This summary is machine-generated.

Direct electrical current (DC) offers a new method to reduce spastic hypertonus by controlled nerve lesioning. This technique demonstrated sustained muscle force reduction in animal models, potentially improving treatment options.

More Related Videos

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

Related Experiment Videos

Last Updated: Jun 5, 2026

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
10:11

Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation

Published on: January 3, 2020

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation
11:07

In Vivo Intracellular Recording of Type-Identified Rat Spinal Motoneurons During Trans-Spinal Direct Current Stimulation

Published on: May 11, 2020

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

Area of Science:

  • Neurology
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Spastic hypertonus, characterized by exaggerated stretch reflexes, commonly affects individuals post-stroke, with cerebral palsy, multiple sclerosis, and spinal cord injury.
  • Current treatments for spastic hypertonus involve nerve lesioning using agents like phenol or botulinum toxin, which can lack precise control.

Purpose of the Study:

  • To investigate the efficacy of direct electrical current (DC) for controlled peripheral nerve lesioning.
  • To evaluate DC lesioning as a potential alternative to existing molecular treatments for spastic hypertonus.

Main Methods:

  • Animal models were utilized to explore the application of direct electrical current (DC) for peripheral nerve lesioning.
  • The study involved controlled application of DC to induce nerve lesions and assess their impact on muscle function.

Main Results:

  • Direct electrical current (DC) successfully reduced muscle force in a controlled manner across animal experiments.
  • The observed reduction in muscle force was sustained for several months, indicating a potentially long-lasting effect.

Conclusions:

  • Controlled DC nerve lesioning presents a viable alternative to current molecular treatments for managing spastic hypertonus.
  • This method offers a more controllable approach to nerve lesioning, potentially leading to improved therapeutic outcomes for neurological conditions causing spasticity.