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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

A feasibility study of a molecular-based patient setup verification method using a parallel-plane PET system.

Satoshi Yamaguchi¹, Masayori Ishikawa, Gerard Bengua

¹Department of Medical Physics and Engineering, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan.

Physics in Medicine and Biology

|January 21, 2011

Summary

This study shows that PET-based molecular image guided radiation therapy (m-IGRT) is feasible. PET-derived planar image registration errors are comparable to radiographic registration, supporting clinical use.

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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

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Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

Area of Science:

Medical Imaging
Radiation Oncology
Nuclear Medicine

Background:

Molecular image guided radiation therapy (m-IGRT) requires accurate patient positioning.
PET-based digitally reconstructed planar image (PDRI) registration is a novel approach for m-IGRT.

Purpose of the Study:

To assess the feasibility of a PET-based m-IGRT system by comparing PDRI registration with radiographic registration.
To evaluate the impact of data acquisition time on registration accuracy.

Main Methods:

A pair of opposing parallel-plane PET systems was used to reconstruct in-plane planar images.
Setup errors were determined using (18)F cylindrical sources of varying sizes and acquisition times (1, 3, 5 min).
Five observers performed image registration using both PDRI and radiographic methods.

Main Results:

The mean registration error for PDRI was 0.93 ± 0.33 mm, statistically similar to radiographic registration (0.92 ± 0.27 mm).
In-plane image resolution (FWHM) was approximately 1.8 mm.
Acquisition time did not significantly affect mean registration error.

Conclusions:

PET-based PDRI registration is feasible for clinical m-IGRT.
Accurate registration can be achieved using in-plane reconstructed PET images.
Performing PDRI registration at two orthogonal gantry angles is recommended for clinical application.