Large scale zebrafish-based in vivo small molecule screen
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Large Scale Zebrafish-Based In vivo Small Molecule Screen
Published on: December 30, 2010
Jijun Hao1, Charles H Williams, Morgan E Webb
1Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine.
Journal of Visualized Experiments : Jove
|January 21, 2011
Abstract:
Given their small embryo size, rapid development, transparency, fecundity, and numerous molecular, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo platform for phenotype-based drug screens and chemical genetic analysis. Here, we demonstrate a simple, practical method for large-scale screening of small molecules using zebrafish embryos.

