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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...

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Related Experiment Video

Updated: Jun 5, 2026

Large Scale Zebrafish-Based In vivo Small Molecule Screen
07:03

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

Large scale zebrafish-based in vivo small molecule screen.

Jijun Hao1, Charles H Williams, Morgan E Webb

  • 1Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine.

Journal of Visualized Experiments : Jove
|January 21, 2011
PubMed
Summary

Zebrafish embryos offer a practical platform for drug discovery. This study presents a simple method for large-scale small molecule screening in zebrafish, advancing chemical genetic analysis.

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Large Scale Zebrafish-Based In vivo Small Molecule Screen
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Published on: December 30, 2010

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Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae
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Small Molecule Screening and Toxicity Testing in Early-stage Zebrafish Larvae

Published on: March 7, 2025

Area of Science:

  • * Developmental Biology
  • * Pharmacology
  • * Genetics

Background:

  • * Zebrafish (Danio rerio) possess numerous traits making them ideal for in vivo studies.
  • * These traits include small embryo size, rapid development, transparency, and high fecundity.
  • * Zebrafish share significant molecular, morphological, and physiological similarities with mammals, facilitating translational research.

Purpose of the Study:

  • * To demonstrate a simple and practical method for large-scale screening of small molecules.
  • * To leverage the zebrafish embryo as an in vivo platform for chemical genetic analysis.
  • * To facilitate phenotype-based drug discovery using zebrafish.

Main Methods:

  • * Utilization of zebrafish embryos as the model system.
  • * Development of a practical, large-scale screening methodology.
  • * Application in chemical genetic analysis and phenotype-based drug screens.

Main Results:

  • * Successful demonstration of a simple and practical method for screening.
  • * Enabled large-scale assessment of small molecules using zebrafish embryos.
  • * Validated the utility of zebrafish for high-throughput drug discovery.

Conclusions:

  • * Zebrafish embryos provide a powerful and efficient in vivo platform for drug screening.
  • * The presented method simplifies and enhances large-scale chemical genetic analysis.
  • * This approach accelerates the identification of potential therapeutic compounds.