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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: Jun 5, 2026

A Method to Study de novo Formation of Chromatin Domains

A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

The Polycomb complex PRC2 and its mark in life.

Raphaël Margueron¹, Danny Reinberg

¹Institut Curie, 26 Rue d'Ulm, 75005 Paris, France.

|January 21, 2011

Summary

This summary is machine-generated.

Polycomb group proteins, including Polycomb repressive complex 2 (PRC2), regulate gene expression and chromatin structure. Recent research highlights non-coding RNA

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

Area of Science:

Epigenetics and Gene Regulation
Chromatin Biology
Developmental Biology

Background:

Polycomb group (PcG) proteins are crucial epigenetic regulators maintaining cellular identity.
Two main mammalian PcG complexes, PRC1 and PRC2, modulate chromatin structure.
PRC2 catalyzes histone H3 lysine 27 methylation, impacting gene expression and cell plasticity.

Purpose of the Study:

To elucidate the regulatory mechanisms and functional roles of Polycomb repressive complex 2 (PRC2).
To investigate the involvement of non-coding RNA in PRC2 recruitment and function.

Main Methods:

Review of recent studies on PRC2 function and regulation.
Analysis of experimental data on PRC2-mediated chromatin modification.
Investigation of non-coding RNA interactions with PRC2.

Main Results:

PRC2 plays a vital role in cell differentiation, identity, proliferation, and stem cell plasticity.
Non-coding RNAs are newly identified key players in recruiting PRC2 to target genes.
PRC2 activity is essential for maintaining developmental gene-expression patterns.

Conclusions:

PRC2 is a central epigenetic regulator with diverse biological functions.
Non-coding RNA-mediated recruitment expands the understanding of PRC2 regulation.
Targeting PRC2 and its regulatory pathways offers potential therapeutic avenues.