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Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

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Related Experiment Video

Updated: Jun 5, 2026

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

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Published on: August 2, 2024

Unusual Complication of ACE Inhibitor-Induced Cough.

R W Swanson

    Canadian Family Physician Medecin De Famille Canadien
    |January 21, 2011
    PubMed
    Summary

    Angiotensin-converting enzyme (ACE) inhibitors like captopril can cause a persistent cough. This cough may lead to rectus abdominis hematoma, a rare but serious complication.

    Area of Science:

    • Pharmacology
    • Internal Medicine
    • Gastroenterology

    Background:

    • Angiotensin-converting enzyme (ACE) inhibitors are widely prescribed for hypertension and heart failure.
    • A persistent dry cough is a known side effect of ACE inhibitors.
    • Rectus abdominis hematoma is a rare clinical condition.

    Purpose of the Study:

    • To report a case of rectus abdominis hematoma secondary to ACE inhibitor-induced cough.
    • To discuss the pathophysiology and incidence of cough associated with ACE inhibitors.

    Main Methods:

    • Case report presentation.
    • Literature review on ACE inhibitor-induced cough and abdominal hematoma.

    Main Results:

    • A patient developed rectus abdominis hematoma following administration of captopril, an ACE inhibitor.

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  • The cough was attributed to the ACE inhibitor, and the hematoma was a consequence of forceful coughing.

    • Conclusions:

    • ACE inhibitor-induced cough, though common, can precipitate rare complications like rectus abdominis hematoma.
    • Clinicians should be aware of this potential association and monitor patients for related symptoms.