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Updated: Jun 5, 2026

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor
Hirotaka Hoshi1, Hikaru Saito, Hiroko Iijima
1Biomedical Research Laboratories, Kureha Corp, 3-26-2, Hyakunin-cho, Shinjuku-ku, Tokyo 169-8503, Japan. h-hoshi@kureha.co.jp
Abstract:
Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. The results obtained suggest that PSK reaches the tumor tissue in its active form and exhibits antitumor effects against MethA cells.
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