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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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[Prostate cancer: a changing disease].

R Cathomas1

  • 1Abteilung Medizinische Onkologie, Kantonsspital Graubünden.

Praxis
|January 21, 2011
PubMed
Summary

Prostate cancer, a common male malignancy, is seeing rapid research advancements. Current treatment options are evolving, with new concepts emerging for localized and advanced disease management.

Area of Science:

  • Oncology
  • Urology

Background:

  • Prostate cancer is the most prevalent malignancy in men.
  • Historically, treatment options for prostate cancer were limited to radical prostatectomy, external beam radiation, and androgen deprivation therapy.
  • Recent years have witnessed significant growth in prostate cancer research across multiple domains.

Purpose of the Study:

  • To summarize current treatment strategies for prostate cancer.
  • To outline emerging treatment possibilities for the near future.
  • To highlight the dynamic changes occurring in prostate cancer care.

Main Methods:

  • Review of current literature on prostate cancer epidemiology, screening, and treatment.
  • Synthesis of established and novel therapeutic approaches.
  • Analysis of recent advancements in understanding prostate cancer biology and management.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization
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Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

Main Results:

  • Prostate cancer research has expanded significantly, covering epidemiology, prophylaxis, screening, and treatment.
  • Established treatments include surgery, radiation, and androgen deprivation.
  • Numerous new questions and treatment avenues are emerging.

Conclusions:

  • The field of prostate cancer treatment is undergoing substantial transformation.
  • Current treatment concepts are rapidly evolving.
  • Future therapeutic strategies are expected to offer improved management for localized and advanced prostate cancer.