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Updated: Jun 5, 2026

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Medical interventions for traumatic hyphema.

Almutez Gharaibeh1, Howard I Savage, Roberta W Scherer

  • 1Department of Special Surgery-Ophthalmology, Faculty of Medicine, The University of Jordan, P.O. Box 13046, Amman, Jordan.

The Cochrane Database of Systematic Reviews
|January 21, 2011
PubMed
Summary
This summary is machine-generated.

Traumatic hyphema rarely causes permanent vision loss, but rebleeding can lead to complications. Antifibrinolytic agents like aminocaproic acid and tranexamic acid may reduce rebleeding risk, though they don

Related Experiment Videos

Last Updated: Jun 5, 2026

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation
09:01

Minimally Invasive Endoscopic Intracerebral Hemorrhage Evacuation

Published on: October 15, 2021

Area of Science:

  • Ophthalmology
  • Trauma Care
  • Evidence-Based Medicine

Background:

  • Traumatic hyphema, or blood in the anterior eye chamber, can cause vision loss, especially with associated injuries or rebleeding.
  • Sickle cell trait/disease increases susceptibility to intraocular pressure elevation and complications.

Purpose of the Study:

  • To assess the effectiveness of medical interventions for traumatic hyphema management.
  • To evaluate treatments for preventing vision loss and complications.

Main Methods:

  • Systematic review of randomized and quasi-randomized controlled trials.
  • Searched multiple databases (CENTRAL, MEDLINE, EMBASE, mRCT, ClinicalTrials.gov) up to June 2010.
  • Included 26 studies with 2,560 participants evaluating various interventions.

Main Results:

  • No intervention significantly improved visual acuity.
  • Antifibrinolytic agents (aminocaproic acid, tranexamic acid) reduced secondary hemorrhage rates.
  • Aminocaproic acid use was linked to longer hyphema resolution times and increased nausea/vomiting.

Conclusions:

  • While no intervention improved visual acuity, antifibrinolytics may reduce rebleeding risk.
  • Individualized treatment decisions are recommended for corticosteroids, cycloplegics, and non-drug interventions due to limited evidence.
  • Further research on combined interventions is warranted.