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Updated: Jun 5, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Published on: August 28, 2015

Nitric oxide-releasing electrospun polymer microfibers.

Peter N Coneski1, Jessica A Nash, Mark H Schoenfisch

  • 1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.

ACS Applied Materials & Interfaces
|January 22, 2011
PubMed
Summary

Researchers developed nitric oxide (NO)-releasing polymer microfibers using electrospinning. These PROLI/NO-doped fibers offer sustained NO release in physiological conditions, outperforming the free donor.

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Area of Science:

  • Biomaterials Engineering
  • Polymer Science
  • Medical Device Technology

Background:

  • Nitric oxide (NO) plays crucial roles in physiological processes.
  • Developing materials for controlled NO release is essential for therapeutic applications.
  • Electrospinning offers a versatile method for fabricating polymer microfibers.

Purpose of the Study:

  • To prepare electrospun polymer microfibers capable of sustained nitric oxide (NO) release.
  • To investigate the influence of material and processing parameters on NO release kinetics.
  • To explore potential applications of these NO-releasing fibers.

Main Methods:

  • Electrospinning of polymer solutions containing disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO).

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  • Characterization of microfiber diameter (100-3000 nm) and NO release under physiological conditions (pH 7.4, 37 °C).
  • Systematic variation of electrospinning parameters (polymer concentration, voltage, flow rate, etc.) and assessment of their impact on fiber properties.

    • Main Results:

    • Successfully fabricated NO-releasing polymer microfibers via electrospinning.
    • Achieved sustained NO release with half-lives 2-200 times longer than the free PROLI/NO donor.
    • Demonstrated that NO release kinetics are dependent on polymer composition and fiber diameter.

    Conclusions:

    • Electrospun polymer microfibers are a viable platform for prolonged nitric oxide delivery.
    • Material and processing parameters significantly influence the performance of NO-releasing fibers.
    • These NO-releasing fibers hold promise for various biomedical applications.