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Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons(*)

Nf Crum-Cianflone1, D Krause, D Wessman

  • 1Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. nancy.crum@med.navy.mil

HIV Medicine
|January 22, 2011
PubMed

Insights

Fatty liver disease may indicate coronary atherosclerosis in HIV-infected adults. Early detection of fatty liver disease warrants cardiovascular disease assessment and risk factor management in this population.

Area of Science:

  • Cardiology
  • Hepatology
  • Infectious Diseases

Background:

  • Cardiovascular disease is a growing concern for individuals with HIV.
  • Identifying markers for coronary atherosclerosis in this population is crucial.

Purpose of the Study:

  • To determine if fatty liver disease is a marker for coronary atherosclerosis in HIV-infected adults.
  • To evaluate the prevalence of and factors associated with subclinical coronary atherosclerosis.

Main Methods:

  • Cross-sectional study of 223 HIV-infected adults.
  • Computed tomography used for coronary artery calcium (CAC) and fatty liver disease assessment.
  • Multivariate logistic regression analyzed factors associated with CAC.

Main Results:

  • 34% of participants had positive CAC scores, indicating coronary atherosclerosis.
  • 13% had fatty liver disease, which was significantly associated with higher CAC scores (P=0.001).
  • Fatty liver disease was an independent predictor of CAC (OR 3.8; P<0.01).

Conclusions:

  • Coronary atherosclerosis is common in young HIV-infected individuals.
  • Fatty liver disease detection in HIV-infected adults necessitates evaluation for cardiovascular disease.
  • Risk factor reduction is recommended for HIV-infected individuals with fatty liver disease.
Abstract

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