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Imprinted Rasgrf1 expression in neonatal mice affects olfactory learning and memory.

N M Drake¹, L M DeVito, T A Cleland

¹Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

Genes, Brain, and Behavior

|January 22, 2011

Summary

Genomic imprinting of Rasgrf1 in neonatal mice is crucial for olfactory associative memory. Disrupting this normal paternal allele expression impairs learning, highlighting its role in early brain development.

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Area of Science:

Neuroscience
Genetics
Developmental Biology

Background:

Genomic imprinting regulates gene expression based on parental origin.
Rasgrf1 is imprinted in the neonatal mouse brain, with paternal allele expression decreasing after weaning.
Previous studies linked Rasgrf1 to learning and memory in adult mice, but its imprinted role in neonates was unknown.

Purpose of the Study:

To investigate the role of normally imprinted Rasgrf1 expression in neonatal learning and memory.
To examine the effects of experimentally manipulated Rasgrf1 imprinting patterns on olfactory associative memory.

Main Methods:

Assessing neonatal mice with altered Rasgrf1 imprinting patterns on an associative olfactory task.
Behavioral assessment of adult mice with manipulated neonatal imprinting.

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Analyzing Rasgrf1 transcript localization and its effect on Ras/Rac activation in the brain.

Main Results:

Neonates lacking the wild-type paternal Rasgrf1 allele showed significant impairment in olfactory associative memory.
Neonatal imprinting manipulation affected adult body weight but not learning and memory.
Imprinted Rasgrf1 was detected in the olfactory bulb and influenced Ras/Rac activation.

Conclusions:

Paternal Rasgrf1 allele expression during the neonatal period is essential for olfactory associative learning.
Rasgrf1 imprinting impacts neonatal brain function, specifically olfactory learning, but not adult cognitive phenotypes.
Rasgrf1 plays a role in neonatal brain development and function through its imprinted expression and downstream signaling pathways.