Related Experiment Videos
[Effect of mitomycin C (MMC) on the fusion points of reciprocal translocations]
B Molina1, S Frías, A Carnevale
1Servicio de Genética, Instituto Nacional de Pediatría, SS, México, D.F.
Abstract:
Lymphocytes from five patients having a reciprocal translocation were exposed to MMC to test the stability of the point of reunion which was localized in an euchromatic region. The results showed that the point of fusion in this type of translocations in not a preferential breakpoint. In a patient carrier of a (1;7) translocation, the derivate chromosome showed a significant increased number of breaks compared with the homologous chromosomes. No explanation is available for this finding. Our results support the hypothesis that the observed dissociation of Robertsonian translocation is related to the fact that the point of reunion is located in a heterochromatic region.
Insights
Reciprocal translocations are not preferential breakpoints. Robertsonian translocations may dissociate due to reunion points in heterochromatic regions, unlike euchromatic regions.
Area of Science:
- Cytogenetics
- Molecular Biology
- Genetics