Related Experiment Videos
[Dopamine antagonists in anovulation?]
U Ulrich1, M Nehmzow, B Krause
1Klinik für Gynäkologie und Geburtshilfe, Ernst-Moritz-Arndt-Universität Greifswald, Berlin.
Zentralblatt Fur Gynakologie
|January 1, 1990
Summary
Dopamine-blocking drug pimozide was tested in women with anovulation resistant to clomiphene citrate. One patient ovulated, suggesting dopaminolytic therapy may help hypothalamic anovulation.
Area of Science:
- Neuroendocrinology
- Reproductive Medicine
Context:
- Hypothalamic dopamine influences ovulatory cycles.
- Anovulation is a common cause of infertility.
- Clomiphene citrate is a standard treatment for anovulation.
Purpose:
- To investigate the efficacy of the dopaminolytic drug pimozide in treating anovulatory menstrual cycles.
- To explore pimozide's potential role in cases of clomiphene citrate resistance.
Summary:
- Ten patients with anovulatory cycles, unresponsive to clomiphene citrate, received pimozide (5 mg/day).
- Treatment was administered either from day 7-11 (7 patients) or day 11-15 (4 patients).
- One patient ovulated, one showed an LH peak without ovulation, and two had slow LH increases.
Impact:
- Suggests a potential therapeutic role for dopaminolytic agents in hypothalamic anovulation.
- Highlights the need for further research into pimozide for infertility treatment.
- Provides preliminary data on LH surge and ovulation induction with pimozide.