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An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Invasive candidiasis in neonates and children
1Third Department of Pediatrics, Aristotle University School of Medicine, Hippokration Hospital, Konstantinoupoleos 49, GR-54642 Thessaloniki, Greece. roilides@med.auth.gr
Early Human Development
|January 22, 2011
Summary
Invasive candidiasis (IC) significantly impacts neonates and children, posing high risks. Early detection and prompt treatment are crucial for managing invasive fungal infections (IFIs) in this vulnerable population.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatology
Background:
- Invasive candidiasis (IC) presents a serious threat to neonates and children, characterized by substantial morbidity and mortality.
- The incidence of IC is notably higher in pediatric populations, especially neonates, compared to adults.
- Key risk factors include prolonged antibiotic use, central venous catheters, parenteral nutrition, and compromised immune systems.
Purpose of the Study:
- To highlight the significant burden of invasive candidiasis in pediatric patients.
- To identify critical risk factors contributing to the development of invasive fungal infections (IFIs) in neonates and children.
- To emphasize the importance of timely diagnosis and treatment for successful outcomes.
Main Methods:
- Literature review of invasive candidiasis in pediatric populations.
- Analysis of risk factors associated with invasive fungal infections.
- Synthesis of current understanding on management strategies.
Main Results:
- Invasive candidiasis demonstrates a higher incidence in children, particularly neonates.
- Identified risk factors include broad-spectrum antibiotics, central venous access, nutritional support, and immune status.
- Necrotizing enterocolitis and low birth weight are significant contributing factors.
Conclusions:
- Effective management of invasive fungal infections in children hinges on early recognition.
- Prompt initiation of appropriate antifungal therapy is essential for improving patient outcomes.
- Vigilance for IC risk factors in neonates and children is paramount for timely intervention.
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