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Updated: Jun 5, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

Drug transporters of platinum-based anticancer agents and their clinical significance

Herman Burger1, Walter J Loos, Karel Eechoute

  • 1Department of Medical Oncology, Erasmus Medical Center Rotterdam-Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. h.burger@erasmusmc.nl

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|January 22, 2011
PubMed

Insights

Platinum-based chemotherapy efficacy is influenced by drug transporters that affect platinum compound uptake and efflux. Understanding these transporters is key to overcoming resistance and improving patient outcomes.

Area of Science:

  • Pharmacology
  • Oncology
  • Molecular Biology

Background:

  • Platinum-based drugs are vital anticancer agents but face resistance, limiting their effectiveness.
  • Mechanisms of impaired platinum drug accumulation, including reduced cellular uptake and increased efflux, are critical challenges.

Purpose of the Study:

  • To review the role of platinum transporters in drug sensitivity and resistance.
  • To discuss the impact of transporters on platinum pharmacokinetics and pharmacodynamics.

Main Methods:

  • Literature review of platinum-based anticancer agents and novel compounds.
  • Analysis of known platinum transporters, focusing on organic cation transporters (OCTs).
  • Discussion of transporter influence on clinical outcomes, resistance, drug interactions, and renal elimination.

Main Results:

  • Active platinum uptake and efflux systems significantly determine sensitivity and resistance to platinum chemotherapy.
  • Organic cation transporters (OCTs) play a crucial role in platinum drug disposition and clinical outcomes.
  • Transporter activity impacts tumor resistance, drug-drug interactions, and renal clearance of platinum compounds.

Conclusions:

  • Targeting platinum transporters presents a strategy to enhance chemotherapy efficacy and overcome resistance.
  • Understanding transporter roles is essential for optimizing platinum-based cancer treatment and managing adverse events.

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