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Updated: Jun 5, 2026
06:47
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Preliminary study on changes in coagulation function and component transfusion time in patients with massive
Dongyou Zheng1, Hong Pan, Xiaoguang Cui
1Department of Anesthesiology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China.
Summary
Massive hemorrhage significantly alters coagulation, decreasing fibrinogen (FIB), hemoglobin (HGB), hematocrit (HCT), and platelets (PLT) while increasing prothrombin time (PT) and activated partial thromboplastin time (APTT). FIB showed the strongest correlation with blood loss.
Area of Science:
- Hematology
- Trauma Surgery
- Critical Care Medicine
Background:
- Massive hemorrhage presents significant challenges in managing coagulation function.
- Understanding dynamic changes in hemostatic parameters is crucial for timely intervention.
Purpose of the Study:
- To investigate the alterations in coagulation function and component transfusion parameters during massive hemorrhage.
- To establish correlations between blood loss volume and specific hemostatic markers.
Main Methods:
- Sixty-two patients with massive hemorrhage were enrolled.
- Blood samples were collected at 1000, 1500, 1700, and 2000 ml blood loss.
- Measured parameters included Fibrinogen (FIB), Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT), Hemoglobin (HGB), Hematocrit (HCT), Platelets (PLT), and Mean Arterial Pressure (MAP).
Main Results:
- Significant decreases in FIB, MAP, HGB, HCT, and PLT were observed with increasing blood loss, falling below baseline values.
- PT and APTT significantly increased progressively with greater blood loss.
- FIB, HCT, and HGB dropped below normal ranges at 1500 ml blood loss, with PT and MAP exceeding normal ranges at 2000 ml.
- FIB demonstrated the strongest correlation with intraoperative blood loss.
Conclusions:
- Intraoperative massive blood loss leads to significant and progressive derangements in coagulation function.
- Fibrinogen levels show the most pronounced correlation with the extent of blood loss, highlighting its importance in monitoring and management.
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