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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jun 5, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Angle closure glaucoma: a mechanistic review.

Monisha E Nongpiur1, Judy Y F Ku, Tin Aung

  • 1Singapore National Eye Centre & Singapore Eye Research Institute, Singapore.

Current Opinion in Ophthalmology
|January 22, 2011
PubMed
Summary
This summary is machine-generated.

Advances in imaging reveal new risk factors for angle closure glaucoma. Understanding iris and lens anatomy, along with physiological changes, improves diagnosis and personalized treatment for this eye condition.

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Related Experiment Videos

Last Updated: Jun 5, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Anatomic and Physiological Studies

Background:

  • Angle closure glaucoma (ACG) pathogenesis is increasingly understood through advanced imaging.
  • Non-pupil block mechanisms and novel risk factors are key areas of recent investigation.

Purpose of the Study:

  • To review recent advances in understanding the pathogenesis of angle closure glaucoma.
  • To highlight novel risk factors and non-pupil block mechanisms contributing to ACG.

Main Methods:

  • Utilizing advanced imaging techniques like anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM).
  • Analyzing anatomical parameters such as iris convexity, area, thickness, lens vault, and anterior chamber dimensions.
  • Investigating physiological factors including dynamic iris volume changes and choroidal expansion.

Main Results:

  • Greater iris convexity, area, and thickness are associated with narrow angles, leading to peripheral iris crowding.
  • Increased lens vault and smaller anterior chamber width, area, and volume are independent risk factors for angle closure.
  • Dynamic iris volume changes and choroidal expansion are observed in primary angle closure glaucoma, though their causal role is unclear.

Conclusions:

  • Enhanced understanding of ACG mechanisms and risk factors aids in identifying at-risk individuals.
  • Advanced imaging tools facilitate tailored treatment strategies based on predominant causative factors.