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Human rotavirus infection in infants and young children with intussusception

T Konno, H Suzuki, T Kutsuzawa

    Journal of Medical Virology
    |January 1, 1978
    PubMed

    Insights

    Human rotavirus infection was detected in 37% of children with intussusception. Further testing showed 70% of these patients had rotavirus, suggesting it as a cause of intussusception in young children.

    Area of Science:

    • Pediatrics
    • Virology
    • Gastroenterology

    Background:

    • Intussusception is a serious condition in infants and young children.
    • The role of infectious agents in intussusception is under investigation.

    Purpose of the Study:

    • To investigate the potential role of human rotavirus as an infectious agent causing intussusception in pediatric patients.

    Main Methods:

    • Electron microscopy was used to detect human rotavirus in stool samples from children with intussusception.
    • Serologic complement fixation tests were performed to identify rotavirus infections.

    Main Results:

    • Human rotavirus was detected in 11 out of 30 infants and young children with intussusception (37%).
    • Serologic tests indicated rotavirus infection in 70% of patients who shed the virus in their stools.

    Conclusions:

    • Human rotavirus is identified as a potential infectious agent contributing to intussusception in infants and young children.
    • Findings suggest rotavirus, alongside adenovirus, may play a role in the etiology of pediatric intussusception.

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