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Updated: Jun 5, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Refining the benefit-risk framework for the assessment of medicines: valuing and weighting benefit and risk
S Walker1, L Liberti, N McAuslane
1CMR International Institute for Regulatory Science, London, UK.
Abstract:
A common framework is necessary for the transparent articulation of the benefits and risks of a therapeutic product across disparate stakeholders. The assignment of value and weighting to each component parameter presents challenges deriving from different stakeholder objectives, methods, and perspectives. Building on prior experiences with a validated framework approach, this forum focused on identifying challenges and approaches to the assignment of values and weightings using a case study applied to a hypothetical medicinal product.
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