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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 5, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

Tracking adult stem cells.

Hugo J Snippert1, Hans Clevers

  • 1Hubrecht Institute, KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.

EMBO Reports
|January 22, 2011
PubMed
Summary
This summary is machine-generated.

Studying adult stem cells in their natural niche is crucial for understanding tissue homeostasis. This review details mouse models and assays for identifying and characterizing stem cells, emphasizing physiological context for accurate interpretation.

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Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
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Last Updated: Jun 5, 2026

Isolating Stem Cells from Soft Musculoskeletal Tissues
07:49

Isolating Stem Cells from Soft Musculoskeletal Tissues

Published on: July 5, 2010

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures
09:06

Isolation of Stem-like Cells from 3-Dimensional Spheroid Cultures

Published on: December 13, 2019

Area of Science:

  • Stem Cell Biology
  • Tissue Homeostasis
  • Mammalian Development

Background:

  • Adult stem cells maintain tissue homeostasis through balanced cell generation and loss.
  • Stem cell function is intimately linked to their microenvironment, termed the niche.
  • Studying stem cells in their physiological context is essential for accurate biological insights.

Purpose of the Study:

  • To review strategies for identifying and functionally characterizing adult stem cells in mice.
  • To discuss the potential, limitations, and interpretations of common stem cell assays.
  • To enhance the understanding of adult stem cell biology through physiologically relevant approaches.

Main Methods:

  • Utilizing the mouse as a model organism for adult mammalian stem cell research.
  • Employing various experimental systems and genetic tools available in mouse models.
  • Focusing on stem cell assays performed within their physiological context.

Main Results:

  • Detailed description of commonly used strategies for adult stem cell identification and functional characterization in mice.
  • Discussion of the strengths and weaknesses of different experimental approaches.
  • Insights into how these methods have advanced the field of adult stem cell biology.

Conclusions:

  • Accurate interpretation of physiologically relevant stem cell assays is critical.
  • Understanding stem cell self-renewal and differentiation requires studying them in their niche.
  • Mouse models provide valuable platforms for advancing adult stem cell research.