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Updated: Jun 5, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

'Haptoglobin concentrations in preterm and term newborns'.

S Chavez-Bueno¹, J A Beasley, J M Goldbeck

¹Department of Pediatrics, Section of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Susana-Chavez-Bueno@ouhsc.edu

Journal of Perinatology : Official Journal of the California Perinatal Association

|January 22, 2011

Summary

Systemic haptoglobin (HPT) is detectable from birth in preterm and term newborns. HPT levels increase in newborns with bacteremia, suggesting its clinical utility in diagnosing neonatal sepsis.

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Transcutaneous Microcirculatory Imaging in Preterm Neonates

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Area of Science:

Neonatal Medicine
Biochemistry
Clinical Diagnostics

Background:

Haptoglobin (HPT) is a protein involved in hemoglobin binding.
Understanding HPT dynamics in newborns is crucial for diagnosing inflammatory conditions.

Purpose of the Study:

To quantify systemic haptoglobin (HPT) concentrations from birth in preterm (PT) and term (T) neonates.
To compare HPT levels in healthy newborns versus those with bacteremia.

Main Methods:

HPT was measured via enzyme-linked immunosorbent assay in PT and T newborns.
Samples were collected at birth, days 2-4, and 1-2 weeks; bacteremic newborns were also assessed.

Main Results:

HPT was consistently detectable from birth in both PT and T neonates.
HPT concentrations significantly increased in newborns aged 2-4 days compared to birth.
Bacteremic newborns exhibited significantly higher HPT levels than non-infected newborns.

Conclusions:

Haptoglobin is a reliable biomarker detectable from birth in neonates.
Elevated HPT levels in newborns correlate with bacteremia.
HPT shows potential clinical utility for evaluating neonatal sepsis.