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Related Concept Videos

Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Pedigree Analysis01:35

Pedigree Analysis

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Pedigree Analysis01:35

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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

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Array Comparative Genomic Hybridization (Array CGH) for Detection of Genomic Copy Number Variants
09:16

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Published on: February 21, 2015

Genetics in pediatrics.

R B Lowry

    Canadian Family Physician Medecin De Famille Canadien
    |January 22, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Genetic disorders significantly impact children, causing over 50% of deaths and 25% of hospital admissions. Recognizing inheritance patterns and genetic heterogeneity is crucial for diagnosis and understanding implications.

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    A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

    Published on: December 1, 2017

    Area of Science:

    • Medical Genetics
    • Pediatric Medicine
    • Clinical Genetics

    Background:

    • Genetic disorders represent a substantial burden in pediatrics, contributing significantly to mortality and hospitalizations.
    • Family history, ethnicity, and consanguinity are vital initial data points for genetic assessment.
    • Distinct inheritance patterns, like X-linked recessive disorders, have specific implications for family members.

    Purpose of the Study:

    • To highlight the significant prevalence and impact of genetic diseases in the pediatric population.
    • To emphasize key diagnostic clues such as family history, ethnicity, and inheritance patterns.
    • To underscore the concept of genetic heterogeneity in pediatric disorders.

    Main Methods:

    • Review of clinical presentation and diagnostic indicators of pediatric genetic disorders.
    • Analysis of epidemiological data on genetic disease impact in children.
    • Discussion of genetic principles including inheritance patterns and heterogeneity.

    Main Results:

    • Genetic diseases account for at least 50% of childhood deaths and 25% of pediatric hospital admissions.
    • Specific findings like male preponderance suggest X-linked recessive inheritance.
    • Chromosomal abnormalities are linked to developmental issues and dysmorphic features.

    Conclusions:

    • Genetic factors are primary drivers of significant pediatric health issues, including mortality and morbidity.
    • A thorough family history and consideration of ethnicity are essential for diagnosing genetic conditions.
    • Understanding genetic heterogeneity is critical as single disease descriptions may encompass multiple genetic causes.