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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: Jun 5, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Alcoholism in the elderly.

S Cohen

    Canadian Family Physician Medecin De Famille Canadien
    |January 22, 2011
    PubMed
    Summary
    This summary is machine-generated.

    This article addresses late-onset alcohol abuse in the elderly, highlighting overlapping symptoms with aging and offering diagnostic laboratory markers for identification and treatment.

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    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
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    Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
    05:12

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    Published on: June 23, 2023

    Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer
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    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
    09:26

    Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

    Published on: February 6, 2019

    Area of Science:

    • Gerontology
    • Addiction Medicine
    • Public Health

    Background:

    • Late-onset alcohol abuse presents unique challenges in geriatric populations.
    • Symptoms can mimic or be mistaken for normal aging processes.
    • Early identification and intervention are crucial for improving health outcomes.

    Purpose of the Study:

    • To detail the identification, confrontation, and treatment strategies for elderly individuals with late-onset alcohol abuse.
    • To review common signs and symptoms shared by aging and problem drinking.
    • To provide a list of laboratory markers for diagnosis and monitoring.

    Main Methods:

    • Literature review focusing on geriatric alcohol abuse.
    • Analysis of overlapping symptoms between aging and alcohol-related issues.
    • Compilation of relevant laboratory diagnostic markers.

    Main Results:

    • Identified overlapping signs and symptoms between aging and late-onset problem drinking.
    • Presented a list of laboratory markers aiding in diagnosis and follow-up.
    • Emphasized the importance of differentiating alcohol-related issues from age-related changes.

    Conclusions:

    • Late-onset alcohol abuse is a significant issue in the elderly that requires specific diagnostic approaches.
    • Recognizing shared symptoms and utilizing laboratory markers can improve detection rates.
    • Effective management involves tailored treatment plans for this demographic.